Pain is the brain’s way our body tells us that something is not working properly and requires our attention. We feel pain as a discharge of a hormones called prostaglandin which is responsible for many roles in the body, including the operation of the brain nerve cells that transmit the sensation of pain. Prostaglandins also cause inflammation in the area where they are excreted and lead to an increase in body temperature following the impact on the part of the brain called the hypothalamus. This critical alert system that prevents us from injuring ourselves or ignore existing damage not handle it – and make it worse.
However, frequently the pain is a nuisance which makes us difficult to function properly even as we have been aware of the damage and treat it. In this case, there are painkillers – chemicals that prevent pain signal to the brain. Analgesics may directly affect the nerve cells that transmit the signal, or as in the case shown in the video – stop the production of prostaglandins that cause a signal to begin.
Most of our senses undergo a process called adaptation (Atnioatzih), that makes us stop to notice the stimulus does not change. Thanks to this we do not notice after a while regular background noise such as an air conditioner or Projector, and mentioning their existence only when the equipment causing the noise suddenly extinguished. For the same reason, if you go to a full stop cooking smells after a few minutes to notice the appetizing aroma, but if you go out into the fresh air and get back in, we will see scented food again.
This mechanism does not always work the same way when it comes to pain. High temperature, for example, causes us to feel pain has been around 45 degrees, long before high temperatures enough to cause us to burn. Parting sink water temperature at 44 degrees, feel slight pain recedes within a few seconds. At a temperature of 46 degrees pain more intense and lasted longer, but as it eventually. At a higher temperature than 48 degrees has been determined to severe pain and immediate, not disappear but rather grow stronger. That informs our nervous system informs us keep the hand before they can cause permanent damage to the body.
As noted in the video, painkillers do not “know” where is the pain, but to reach all parts of the body and inhibits the production process including prostaglandins. One of the places to which they arrive is the area of the brain called the “hypothalamus”, responsible for the balance of many biological processes, including maintaining normal body temperature. One of the reasons our body heat rising in our sickness is prostaglandins produced in the hypothalamus and act on nerve cells in the area responsible for regulating body temperature. Because of this, analgesics prevent prostaglandin formed also help to reduce the heat and return the body temperature to normal.
Analgesics are divided into two main types: anti-inflammatory relieve non-steroidal (NSAID) such as aspirin and ibuprofen shown in the video, and analgesics or opioids (Such as hydrocodone or oxycodone). Pacifier opioid bind to receptors in the nervous system and cause anesthesia, increasing the resistance to pain, reduce the perception of pain and create a feeling of euphoria. These materials are relatively strong and can cause unpleasant side effects and addiction, so they are usually only prescribed by doctors when there is clear medical need.
The Pain killers which are mentioned in the video, have a prominent role in the chain of thatch they inhibit the enzymes that synthesize prostaglandins, may have side effects. The use of specific, relatively easy these phenomena and these materials are not considered addictive, so you can get them without a prescription. However, too frequent use or excessive which can cause side effects such as loss of bowel and kidneys.